<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "https://jats.nlm.nih.gov/publishing/1.3/JATS-journalpublishing1-3.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" dtd-version="1.3" xml:lang="en">
<front>
<journal-meta>
  <journal-id journal-id-type="publisher-id">58</journal-id>
  <journal-id journal-id-type="short-title">gdddr</journal-id>
  <journal-id journal-id-type="doi">10.31703/gdddr</journal-id>
  <journal-title-group>
    <journal-title>Global Drug Design &amp; Development Review</journal-title>
    <abbrev-journal-title abbrev-type="publisher">gdddr</abbrev-journal-title>
  </journal-title-group>
  <issn publication-format="print">2788-497X</issn>
  <issn publication-format="electronic">2788-4120</issn>
  <self-uri xlink:href="https://gdddrjournal.com"/>
  <publisher>
    <publisher-name>Humanity Publications</publisher-name>
    <publisher-loc>Pakistan</publisher-loc>
  </publisher>
</journal-meta>
<article-meta>
  <article-id pub-id-type="publisher-id">394819</article-id>
  <article-id pub-id-type="doi">10.31703/gdddr.2023(VIII-II).11</article-id>
  <article-id pub-id-type="other" specific-use="submission-id">5286</article-id>
  <article-version article-version-type="publisher">1.0</article-version>
  <article-categories>
    <subj-group subj-group-type="heading">
      <subject>article</subject>
    </subj-group>
  </article-categories>
  <title-group>
    <article-title xml:lang="en">Drug vs Self-Care Management of Gestational Diabetes Mellitus: Knowledge and Practices of Women Attending Antenatal Clinics of Faisalabad</article-title>
  </title-group>
<contrib-group>
  <contrib contrib-type="author" seq="1" corresp="yes">
    <name>
      <surname>Riaz</surname>
      <given-names>Maham</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing – original draft</role>
    <xref ref-type="aff" rid="aff1"/>
    <xref ref-type="corresp" rid="cor1"/>
  </contrib>
  <contrib contrib-type="author" seq="2">
    <name>
      <surname>Fazeelat</surname>
      <given-names>Rabia</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff1"/>
  </contrib>
  <contrib contrib-type="author" seq="3">
    <name>
      <surname>Kousar</surname>
      <given-names>Shazia</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff2"/>
  </contrib>
  <contrib contrib-type="author" seq="4">
    <name>
      <surname>Fatima</surname>
      <given-names>Noor</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff3"/>
  </contrib>
  <aff id="aff1">
    <label>1</label>
    <institution-wrap>
      <institution>General Nurse, Children Hospital Faisalabad</institution>
    </institution-wrap>
    <addr-line>Punjab</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff2">
    <label>2</label>
    <institution-wrap>
      <institution>General Nurse, Allied Hospital Faisalabad</institution>
    </institution-wrap>
    <addr-line>Punjab</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff3">
    <label>3</label>
    <institution-wrap>
      <institution>General Nurse, Aziz Fatima Hospital, Faisalabad</institution>
    </institution-wrap>
    <addr-line>Punjab</addr-line>
    <country>Pakistan</country>
  </aff>
</contrib-group>
<author-notes>
  <corresp id="cor1">Corresponding Author: Maham Riaz, General Nurse, Children Hospital Faisalabad, Punjab, Pakistan.</corresp>
<fn fn-type="COI-statement" id="fn-coi">
  <p>The authors declare that they have no conflicts of interest.</p>
</fn>
<fn fn-type="ethics-statement" id="fn-ethics">
  <p>This study did not require formal ethics approval.</p>
</fn>
<fn fn-type="data-availability-statement" id="fn-data">
  <p>Data sharing is not applicable to this article.</p>
</fn>
</author-notes>
<pub-date pub-type="epub" date-type="pub" publication-format="electronic">
  <day>30</day>
  <month>06</month>
  <year>2023</year>
</pub-date>
<pub-date pub-type="collection">
  <month>06</month>
  <year>2023</year>
</pub-date>
<pub-date date-type="pub" publication-format="print">
  <day>22</day>
  <month>05</month>
  <year>2023</year>
</pub-date>
  <volume>8</volume>
  <issue>2</issue>
  <season>Spring</season>
  <fpage>80</fpage>
  <lpage>88</lpage>
  <history>
    <date date-type="accepted">
      <day>22</day>
      <month>05</month>
      <year>2023</year>
    </date>
  </history>
<funding-group>
  <funding-statement>
<p>The authors received no specific funding for this work.</p>
  </funding-statement>
</funding-group>
<permissions>
  <copyright-year>2023</copyright-year>
  <copyright-holder>Humanity Publications</copyright-holder>
  <license license-type="open-access" xml:lang="en" xlink:href="https://creativecommons.org/licenses/by/4.0/">
    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License.</license-p>
  </license>
</permissions>
<self-uri content-type="text/html" xlink:href="https://gdddrjournal.com/article/drug-vs-selfcare-management-of-gestational-diabetes-mellitus-knowledge-and-practices-of-women-attending-antenatal-clinics-of-faisalabad"/>
<self-uri content-type="pdf" xlink:href="https://gdddrjournal.com/pdf/gdddr/wxXbFx3Cbi.pdf"/>
<supplementary-material id="suppl-pdf" content-type="pdf" xlink:href="https://gdddrjournal.com/pdf/gdddr/wxXbFx3Cbi.pdf">
  <label>PDF</label>
  <caption>
    <title>Full Text PDF</title>
  </caption>
</supplementary-material>
  <abstract>
    <p>Gestational diabetes mellitus is a significant and growing global health issue. Objectives: To assess the knowledge of women attending antenatal clinics in Faisalabad regarding GDM and its selfâ€care management practices. Methodology: A descriptive crossâ€sectional study. The study&apos;s duration was 4 months from February 2023 to May 2023 and study setting areas included Allied Hospital Faisalabad and District Head Quatre Hospital Faisalabad. The population included women attending antenatal clinics in Faisalabad regarding GDM and its selfâ€care management practices were assessed using a selfâ€structured questionnaire. Results: Among the total of 384 participants, the majority (253; 65.9%) were less than 30 years old. Mostly (365; 95.1%) women are married. Mostly (201; 52.3%) are 26â€30 years old during marriage. Mostly (160; 41.7%) are 1â€5 Years have passed years of marriage. The results revealed that the majority of the participant nurses had an average level of practice 49.99%, below average level of attitude 22.52% and a satisfactory level of knowledge, 82.33%.</p>
  </abstract>
<kwd-group kwd-group-type="author-keywords">
  <kwd>Knowledge GDM</kwd>
  <kwd>Selfâ€Care and Management Practices</kwd>
</kwd-group>
  <custom-meta-group>
    <custom-meta><meta-name>views</meta-name><meta-value>451</meta-value></custom-meta>
    <custom-meta><meta-name>downloads</meta-name><meta-value>0</meta-value></custom-meta>
    <custom-meta><meta-name>html-views</meta-name><meta-value>0</meta-value></custom-meta>
    <custom-meta><meta-name>google-scholar-citations</meta-name><meta-value>0</meta-value></custom-meta>
    <custom-meta><meta-name>crossref-citations</meta-name><meta-value>0</meta-value></custom-meta>
  </custom-meta-group>
</article-meta>
</front>
<body>
<sec id="sec-1">
  <title>Introduction</title>
<p>Gestational diabetes mellitus (GDM) is a growing global health concern, characterized by diabetes detected during the second or third pregnancy period without any preexisting type 1 or type 2 diabetes (Baz, Riveline, &amp; Gautier, 2016). Globally, GDM affects 7-10% of pregnancies and is a significant health concern, according to world data estimates (Creanga, Catalano, &amp; Bateman, 2022). GDM, a condition typically resolved post-childbirth, can have long-term medical effects on both the mother and child, increasing the risk of miscarriage, macrosomia, delivery complications, and stillbirth. (McIntyre et al., 2019). The prevalence of gestational diabetes mellitus (GDM) exhibits significant variation worldwide, influenced by demographic factors including maternal age, socioeconomic status, race/ethnicity, and body composition. This variability is further compounded by variations in screening protocols and diagnostic criteria used across different regions. Consequently, reported prevalence rates of GDM range widely, spanning from as low as 1% to as high as 28% across different populations. Gestational diabetes mellitus (GDM) may also be influenced by genetic factors, similar to the conventional manifestation of type 2 diabetes. These hereditary characteristics may contribute to differential impacts on the prevalence of the illness across different population groups (Plows et al., 2018).</p><p>There is a dearth of comprehensive research pertaining to gestational diabetes mellitus (GDM) on a large scale within the context of Pakistan. Nevertheless, previous investigations conducted in smaller hospital settings have shown a frequency ranging from 3.3% to 8%. The variation in screening methodologies used by various researchers poses challenges in determining the present state of gestational diabetes mellitus (GDM) within this nation (Riaz et al., 2019). Several recent large-scale clinical trials have shown a correlation between early identification and intensive treatment of gestational diabetes and reduced rates of maternal and fetal morbidity and mortality (Riaz et al., 2019). In order to mitigate the occurrence of congenital abnormalities and other health complications, it is important for expectant mothers to maintain optimal physical well-being both before and during the duration of their pregnancy. The incorporation of other disciplines is important in order to attain this objective. According to a new release by the World Health Organization (WHO), there is an increased likelihood of encountering complications during pregnancy and delivery among women diagnosed with gestational diabetes. Mothers who exhibit certain characteristics are more likely to have an elevated risk of developing type 2 diabetes in the future, and this risk is also anticipated to extend to their offspring (Jabeen et al., 2022).</p><p>Based on data provided by the International Diabetes Federation (IDF), it is estimated that around 16.8% of pregnancies, equivalent to one in six pregnancies, are affected by diabetes within this particular range. The prevalence of gestational diabetes mellitus (GDM) is seen in a significant proportion, namely 86.4%, of the population. Conversely, a smaller subset of individuals, including 13.6% of women, experience gestational diabetes (Fang et al., 2021). According to cohort research conducted in Sweden, it was shown that women with diabetes have reduced fertility, which is expected to be consistent with the frequency of diabetes in the general population (Liu et al., 2022).</p><p>Management of gestational diabetes typically involves making lifestyle changes, such as eating a healthy diet, getting regular exercise, and maintaining a healthy weight. Additionally, blood sugar levels will be monitored and medications, such as insulin, may be prescribed if needed. Close monitoring of fetal growth and well-being, as well as testing for diabetes after delivery, are also important for managing gestational diabetes. It is important to work closely with a healthcare provider to develop an individualized treatment plan (Rasmussen et al., 2020).</p><p>Therefore, this study aims to assess the knowledge and practices of women attending antenatal clinics in Faisalabad regarding self-care management of GDM. The findings of this study will provide insights into the current status of GDM self-care management in Faisalabad and identify potential strategies to improve self-care management practices. The study will contribute to the existing literature on the barriers to effective self-care management of GDM and inform healthcare providers and policymakers on how to improve the health outcomes of women with GDM in Faisalabad.</p><p>The significance of the study is a statement that explains the potential impact and importance of the research. It highlights the value of the study and its potential contributions to the field of nursing and maternal health. In the case of this B.Sc Nursing thesis, the significance of the study for the topic &quot;Self-care Management of Gestational Diabetes Mellitus: Knowledge and Practices of Women Attending Antenatal Clinics of Faisalabad&quot; is Gestational diabetes mellitus (GDM) is a significant health issue that can have adverse outcomes for both the mother and fetus. The prevention and management of GDM through effective self-care management practices are crucial in ensuring better health outcomes for both. Therefore, assessing the knowledge and practices of women attending antenatal clinics in Faisalabad regarding self-care management of GDM is important to improve the quality of care provided to pregnant women with GDM. This study will provide valuable insights into the current knowledge and practices of women attending antenatal clinics in Faisalabad regarding self-care management of GDM. It will also identify the barriers to effective self-care management of GDM in Faisalabad, Pakistan, and provide recommendations to improve the knowledge and practices of women attending antenatal clinics in Faisalabad.</p><p><break/></p><p>Objectives</p><p>The objectives of the current study are:</p><p>1.	To assess the knowledge of women attending antenatal clinics in Faisalabad regarding GDM and its self-care management practices.</p><p>2.	To evaluate the practices of women attending antenatal clinics in Faisalabad regarding GDM and its self-care management practices.</p><p>3.	To identify the barriers to effective self-care management of GDM among women attending antenatal clinics in Faisalabad.</p>
</sec>
<sec id="sec-2">
  <title>Methodology</title>
<p><break/></p><p>Study Design</p><p>A descriptive cross-sectional study design was used.</p><p><break/></p><p>Settings</p><p>Allied hospital and DHQ hospital Faisalabad.</p><p><break/></p><p>Duration of Study</p><p>4 months from February to May 2023</p><p><break/></p><p>Target population</p><p>Pregnant women come to antenatal clinics (outdoor patient departments) of study hospitals.</p><p>Sample Size: 384</p><p>n = Z2 1-?/2 p (1-p)/ d2</p><p>Z =1st Standard normal variate error at 95% = 1.96</p><p>P= Expected proportion in population in Previous Study (50%)</p><p>d= Absolute error or Precision = 0.05</p><p>n= sample size = 384</p><p><break/></p><p>Sampling Technique</p><p>Convenient sampling technique.</p><p><break/></p><p>Sample Selection</p><p>?	Inclusion Criteria: Pregnant women who have been clinically diagnosed with GDM and are attending antenatal clinic (OPD) of study hospitals.</p><p>?	Exclusion Criteria: Pregnant women attending antenatal clinics (OPDs) but not diagnosed with GDM.</p><p><break/></p><p>Data Collection Procedure</p><p>After taking the approval form from the authority and signed by the supervisor. We shall go to DHQ and allied hospital FSD for data collection and meet with the medical superintendent and Nursing superintendent for permission for data collection. Then we shall meet the pregnant women with GDM and introduce our research topic. After consent from the subjects, we shall collect our data. While conducting the interviews, the participants are permitted to respond to the questions according to the choice of their language.</p><p><break/></p><p>Data Collection Tool</p><p>Self-structured questionnaire on GDM self-care</p><p>management involving knowledge and practice-based questions.</p><p><break/></p><p><break/></p><p>Data Analysis Procedure</p><p>SPSS software version 26 was used and descriptive statistics were calculated.</p>
</sec>
<sec id="sec-3">
  <title>Results</title>
<p>management
of gestational diabetes mellitus: knowledge and practices of women attending
antenatal clinics of Faisalabad. The sample for this study was selected from
384 Pregnant women coming from antenatal clinics (outdoor patient departments)
of study hospitals. The sample was collected using an intentional sampling
strategy. SPSS version 26 was used to search the findings. The study&apos;s findings
are reported in tabular form in this chapter.</p> <p><break/></p>  <p><bold>Demographic Information</bold></p> <table-wrap id="table1"><label>Table
1</label><caption><title>Detail information of all demographic information
(N=384).</title></caption><table><thead><tr><th> <p><bold>Age</bold></p> </th><th> <p><bold>Frequency</bold></p> </th><th> <p><bold>%</bold></p> </th></tr></thead><tbody><tr><td> <p>18-25</p> </td><td> <p>18</p> </td><td> <p>4.7%</p> </td></tr><tr><td> <p>26-30</p> </td><td> <p>7</p> </td><td> <p>1.8%</p> </td></tr><tr><td> <p>31-35</p> </td><td> <p>50</p> </td><td> <p>13.0%</p> </td></tr><tr><td> <p>36-40</p> </td><td> <p>197</p> </td><td> <p>51.3%</p> </td></tr><tr><td> <p>41
  &amp; above</p> </td><td> <p>112</p> </td><td> <p>29.2%</p> </td></tr><tr><td> <p><bold>Age
  at Marriage</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>18-25</p> </td><td> <p>43</p> </td><td> <p>11.2%</p> </td></tr><tr><td> <p>26-30</p> </td><td> <p>29</p> </td><td> <p>7.6%</p> </td></tr><tr><td> <p>31-35</p> </td><td> <p>212</p> </td><td> <p>55.2%</p> </td></tr><tr><td> <p>36
  &amp; above</p> </td><td> <p>100</p> </td><td> <p>26.0%</p> </td></tr><tr><td> <p><bold>No
  of Children</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>Zero</p> </td><td> <p>124</p> </td><td> <p>32.3%</p> </td></tr><tr><td> <p>One</p> </td><td> <p>127</p> </td><td> <p>33.1%</p> </td></tr><tr><td> <p>Multiple</p> </td><td> <p>133</p> </td><td> <p>34.6%</p> </td></tr><tr><td> <p><bold>Pregnancy
  in Months</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>1
  to 3 months</p> </td><td> <p>145</p> </td><td> <p>37.8%</p> </td></tr><tr><td> <p>4
  to 6 months</p> </td><td> <p>110</p> </td><td> <p>28.6%</p> </td></tr><tr><td> <p>7
  to 9 months</p> </td><td> <p>129</p> </td><td> <p>33.6%</p> </td></tr><tr><td> <p><bold>Education</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>Illiterate</p> </td><td> <p>100</p> </td><td> <p>26.0%</p> </td></tr><tr><td> <p>Primary</p> </td><td> <p>81</p> </td><td> <p>21.1%</p> </td></tr><tr><td> <p>Secondary</p> </td><td> <p>90</p> </td><td> <p>23.4%</p> </td></tr><tr><td> <p>Bachelor</p> </td><td> <p>88</p> </td><td> <p>22.9%</p> </td></tr><tr><td> <p>Master</p> </td><td> <p>25</p> </td><td> <p>6.5%</p> </td></tr><tr><td> <p><bold>Occupation</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>Unemployed</p> </td><td> <p>118</p> </td><td> <p>30.7%</p> </td></tr><tr><td> <p>Self-employed</p> </td><td> <p>87</p> </td><td> <p>22.7%</p> </td></tr><tr><td> <p>Formal
  employed</p> </td><td> <p>107</p> </td><td> <p>27.9%</p> </td></tr><tr><td> <p>Professional</p> </td><td> <p>32</p> </td><td> <p>8.3%</p> </td></tr><tr><td> <p>Other</p> </td><td> <p>40</p> </td><td> <p>10.4%</p> </td></tr><tr><td> <p><bold>Family
  Income</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>Less
  than 15,000</p> </td><td> <p>114</p> </td><td> <p>29.7%</p> </td></tr><tr><td> <p>15,000
  to 20,000</p> </td><td> <p>86</p> </td><td> <p>22.4%</p> </td></tr><tr><td> <p>21,000
  to 30,000</p> </td><td> <p>113</p> </td><td> <p>29.4%</p> </td></tr><tr><td> <p>31,000
  to 40,000</p> </td><td> <p>36</p> </td><td> <p>9.4%</p> </td></tr><tr><td> <p>More
  than 40,000</p> </td><td> <p>35</p> </td><td> <p>9.1%</p> </td></tr><tr><td> <p><bold>Living
  Arrangements</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>Living
  in a nuclear family</p> </td><td> <p>126</p> </td><td> <p>32.8%</p> </td></tr><tr><td> <p>Living
  in an extended family</p> </td><td> <p>124</p> </td><td> <p>32.3%</p> </td></tr><tr><td> <p>Others</p> </td><td> <p>134</p> </td><td> <p>34.9%</p> </td></tr><tr><td> <p><bold>Weight
  in kg</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>55-60kg</p> </td><td> <p>63</p> </td><td> <p>16.4%</p> </td></tr><tr><td> <p>61-80
  kg</p> </td><td> <p>73</p> </td><td> <p>19.0%</p> </td></tr><tr><td> <p>81-100
  kg</p> </td><td> <p>63</p> </td><td> <p>16.4%</p> </td></tr><tr><td> <p>More
  than 100 kg</p> </td><td> <p>185</p> </td><td> <p>48.2%</p> </td></tr><tr><td> <p><bold>Blood
  glucose level</bold></p> </td><td colspan="2"></td></tr><tr><td> <p>Less
  than 95 mg/dL</p> </td><td> <p>59</p> </td><td> <p>15.4%</p> </td></tr><tr><td> <p>96-135
  mg/dL</p> </td><td> <p>70</p> </td><td> <p>18.2%</p> </td></tr><tr><td> <p>More
  than 136 mg/dL</p> </td><td> <p>255</p> </td><td> <p>66.4%</p> </td></tr></tbody></table></table-wrap>  <p><break/></p> <p>Table 1 presents
various demographic and health-related statistics. Following is an
interpretation of the information:</p> <p><bold>Age distribution:</bold> The table shows that
the majority of the surveyed population falls within the age range of 36-40
years, constituting 51.3% of the sample. The next significant age group is
individuals aged 41 and above, comprising 29.2% of the participants. The
younger age brackets of 18-25 and 26-30 represent 4.7% and 1.8% of the
respondents, respectively. The group aged 31-35 accounts for 13.0% of the
population.</p> <p><bold>Age at Marriage:</bold> Examining the age at
which individuals got married, it is notable that the largest portion, 55.2%,
falls within the range of 31-35 years old. A considerable number of
respondents, 26.0%, got married at the age of 36 and above. The age groups
18-25 and 26-30 account for 11.2% and 7.6% of the sample, respectively.</p> <p><bold>Number of Children:</bold> The table reveals
that the distribution of the number of children is relatively balanced among
the surveyed individuals. The group with zero children constitutes 32.3% of the
respondents, closely followed by those with one child at 33.1%. The remaining
34.6% consists of participants with multiple children.</p> <p><bold>Pregnancy in Months:</bold> Looking at the
duration of pregnancies, the table indicates that the highest percentage,
37.8%, corresponds to pregnancies in the early stage, specifically 1 to 3
months. Pregnancies lasting 4 to 6 months account for 28.6% of the sample, and
the remaining 33.6% represent pregnancies in the later stage, namely 7 to 9
months.</p> <p><bold>Education:</bold> When considering the
educational background of the participants, it is observed that the majority
have completed secondary education, comprising 23.4% of the sample. Bachelor&apos;s
degree holders make up 22.9% of the respondents, while primary education and
illiterate individuals constitute 21.1% and 26.0%, respectively. A smaller
proportion, 6.5%, holds a master&apos;s degree.</p> <p><bold>Occupation:</bold> The occupation
distribution among the surveyed individuals reveals that the highest
percentage, 30.7%, consists of unemployed individuals. The second largest group
is self-employed individuals, accounting for 22.7% of the respondents. Formal
employment is reported by 27.9% of the sample, while 8.3% are engaged in
professional occupations. The remaining 10.4% falls under the &quot;Other&quot;
category.</p> <p><bold>Family Income:</bold> Analyzing the income
levels, it is found that the largest percentage, 29.7%, corresponds to families
with a monthly income of less than 15,000 units. Income ranges between 15,000
and 20,000 units are reported by 22.4% of the respondents, while 29.4% fall
within the range of 21,000 to 30,000 units. A smaller proportion, 9.4%,
represents families with an income between 31,000 and 40,000 units, and 9.1%
have a monthly income exceeding 40,000 units.</p> <p><bold>Living Arrangements:</bold> The table
demonstrates that the respondents are fairly evenly distributed across
different living arrangements. Living in a nuclear family is reported by 32.8%
of the participants, closely followed by those living in an extended family at
32.3%. The remaining 34.9% represent individuals who reside in other living
arrangements not specified in the table.</p> <p><bold>Weight:</bold> Examining the weight
distribution, the table indicates that the majority of respondents, 48.2%, have
a weight exceeding 100 kg. The weight ranges of 55-60 kg and 81-100 kg are
reported by 16.4% each. Individuals weighing between 61-80 kg represent 19.0%
of the sample.</p> <p><bold>Blood Glucose Level:</bold> The table reveals
that a significant percentage, 66.4%, of the surveyed population has a blood
glucose level above 136 mg/dL, which may indicate higher than normal blood
sugar levels. The range of 96-135 mg/dL is reported by 18.2% of the respondents,
while less than 95 mg/dL is reported by 15.4% of the sample.</p> <p><break/></p>  <table-wrap id="table2"><label>Table 2</label><caption><title>Knowledge and Practice among Gestational Diabetes
Mellitus Women (N=384).</title></caption><table><tbody><tr><td rowspan="2">  </td><td colspan="3"> <p><bold>Knowledge</bold></p> </td><td rowspan="2"> <p><bold>Total</bold></p> </td></tr><tr><td> <p><bold>Yes</bold></p> </td><td> <p><bold>No</bold></p> </td><td> <p><bold>Don’t know</bold></p> </td></tr><tr><td rowspan="3"> <p>Practice</p> </td><td> <p>44</p> </td><td> <p>43</p> </td><td> <p>35</p> </td><td> <p>122</p> </td></tr><tr><td> <p>41</p> </td><td> <p>48</p> </td><td> <p>43</p> </td><td> <p>132</p> </td></tr><tr><td> <p>43</p> </td><td> <p>36</p> </td><td> <p>51</p> </td><td> <p>130</p> </td></tr><tr><td> <p>Total</p> </td><td> <p>128</p> </td><td> <p>127</p> </td><td> <p>129</p> </td><td> <p>384</p> </td></tr></tbody></table></table-wrap> <p>?<sup>2 </sup>= 4.369a</p>  <p><break/></p><p>Table
2 determines whether the association between knowledge and practice is
statistically significant, you would typically perform a chi-squared test of
independence. This test would involve comparing the observed ?² value of 4.369
to a critical ?² value from a chi-squared distribution with degrees of freedom
determined by the size of the table and a chosen significance level (0.05). The
?² statistic is a measure of how much the observed frequencies in the table
differ from what would be expected if there were no association between
knowledge and practice. In this case, ?² is calculated to be 4.369.</p>
</sec>
<sec id="sec-4">
  <title>Figure 1</title>
<p>Knowledge and Practice among Gestational Diabetes Mellitus Women</p>
</sec>
<sec id="sec-5">
  <title>Discussion</title>
<p>This chapter presents a detailed discussion of the findings of the research. The findings are related back to the research questions and objectives and are compared and contrasted with findings from existing literature. The knowledge of GDM among women attending antenatal clinics in Faisalabad was found to be diverse. A significant proportion of participants demonstrated a good understanding of the disease, its implications, and self-care practices. However, a considerable number of participants showed inadequate knowledge, which is a concern. This is consistent with studies by Schaefer-Graf et al., (2020), who reported variable levels of knowledge about GDM among pregnant women. The importance of understanding GDM for its successful self-management cannot be understated, as emphasized by Chasan-Taber (2019).</p><p>Participants&apos; self-care practices for GDM also varied greatly. Some women adhered strictly to recommended dietary practices, regular exercise, and blood glucose monitoring, while others reported inconsistent adherence. This finding is similar to those of Carolan et al., (2017) who noted variable adherence to self-care practices among women diagnosed with GDM. They attributed this variation to differences in patient education, socioeconomic status, and cultural beliefs.</p><p>One of the significant findings of this study was the identification of several barriers that hinder effective self-care management of GDM. These include lack of understanding of the importance of self-care, lack of time due to work or family responsibilities, financial constraints, lack of support from family members, and cultural beliefs. This observation resonates with the findings of Kaptein et al., (2020), who reported similar barriers in their study. These barriers have serious implications as they could lead to poor management of GDM, potentially endangering both maternal and fetal health. Despite these findings, it should be noted that this study has limitations. The use of convenience sampling may limit the generalizability of the findings, as the sample might not be representative of all pregnant women with GDM in Faisalabad. Additionally, self-reported practices might suffer from social desirability bias. Many women possess knowledge about GDM and are engaging in effective self-care practices, there is a significant proportion that lack adequate knowledge and are unable to consistently adhere to self-care practices due to several barriers. While this study provides valuable insights into the knowledge, practices, and barriers related to the self-care management of GDM among women attending antenatal clinics in Faisalabad, certain limitations must be acknowledged. This study has provided valuable insights into the knowledge, practices, and barriers related to self-care management of GDM among women attending antenatal clinics in Faisalabad. The findings from this study can inform the development of educational and support programs tailored to the needs and contexts of these women, which can improve their self-care practices and enhance their health outcomes. Remember to include specific findings from your study in the appropriate places and compare your results with previous research. The discussion should revolve around your research questions and objectives and should provide a deeper understanding of your findings.</p>
</sec>
<sec id="sec-6">
  <title>Conclusion</title>
<p>This study set out to investigate the knowledge, practices, and barriers to self-care management of gestational diabetes mellitus (GDM) among pregnant women attending antenatal clinics in Faisalabad. The conclusions drawn from this study are as follows: Knowledge about GDM and its self-management practices is variable among pregnant women in Faisalabad. While some women demonstrate a good understanding, others lack crucial knowledge. This underscores the need for effective health education programs targeting this demographic, with the aim to enhance their understanding of GDM and its management. The self-care practices adopted by these women also vary greatly. Despite some women demonstrating commendable adherence to recommended practices, a significant number do not follow these guidelines consistently. It is therefore crucial to promote better adherence to self-care practices among these women. Various barriers to effective self-care management of GDM were identified, including lack of understanding, time constraints, financial limitations, lack of family support, and cultural beliefs. These findings highlight the need for interventions addressing these barriers, in order to improve self-care practices and overall health outcomes.</p><p>Despite these insights, the study had limitations. The findings may not be generalizable due to the use of convenience sampling. Furthermore, the use of self-reported measures may have introduced bias. Moving forward, healthcare providers and policymakers should consider these findings in their efforts to enhance the management of GDM among pregnant women. Interventions that aim to improve knowledge, facilitate effective self-care practices, and address the identified barriers could potentially improve the health outcomes of both the mother and the fetus. Future research should aim to validate these findings in larger and more diverse populations and explore effective strategies to address the identified gaps. These conclusions, derived from the findings of this study, underscore the importance of comprehensive and tailored interventions for pregnant women with GDM. Given the potential complications of GDM for both the mother and the child, the importance of these interventions cannot be overstated.</p>
</sec>
<sec id="sec-7">
  <title>Recommendations</title>
<p>Based on the findings and conclusions of this study, the following recommendations can be made:</p><p>1.	There is a need for comprehensive health education programs for pregnant women at antenatal clinics. These programs should aim to enhance women&apos;s understanding of GDM, its potential complications, and the importance of self-care management.</p><p>2.	Healthcare providers should regularly assess the knowledge and practices of pregnant women with GDM to identify gaps and provide appropriate guidance. They should emphasize the importance of adhering to recommended dietary practices, regular exercise, and blood glucose monitoring.</p><p>3.	Given the influence of cultural beliefs identified in this study, culturally sensitive approaches should be incorporated into health education programs and counselling. This could include collaborating with community leaders or using culturally appropriate materials and communication methods.</p><p>4.	Policymakers should consider these findings in their efforts to enhance maternal health. They could develop policies that promote health education and provide resources for pregnant women with GDM. This could include subsidies for medical supplies or the provision of free or low-cost educational resources.</p><p>5.	More research is needed to validate the findings of this study in larger and more diverse populations. Future research could also explore the effectiveness of different interventions in improving the knowledge and practices of pregnant women with GDM, and in overcoming the identified barriers.</p>
</sec>
</body>
<back>
<fn-group content-type="conflict-of-interest">
  <title>Conflict of Interest</title>
  <fn fn-type="conflict">
<p>The authors declare that they have no conflicts of interest.</p>
  </fn>
</fn-group>
<fn-group content-type="ethics-statement">
  <title>Ethics Statement</title>
  <fn fn-type="ethics">
<p>This study did not require formal ethics approval.</p>
  </fn>
</fn-group>
<fn-group content-type="data-availability">
  <title>Data Availability</title>
  <fn fn-type="data-availability-statement">
<p>Data sharing is not applicable to this article.</p>
  </fn>
</fn-group>
<app-group>
  <app id="app-suppl">
    <title>Supplementary Materials</title>
<supplementary-material id="suppl-pdf" content-type="pdf" xlink:href="https://gdddrjournal.com/pdf/gdddr/wxXbFx3Cbi.pdf">
  <label>PDF</label>
  <caption>
    <title>Full Text PDF</title>
  </caption>
</supplementary-material>
  </app>
</app-group>
<ref-list>
  <title>References</title>
<ref id="Suri">
  <label>1</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Suri, S. S. H., &amp;Fenniri, B</person-group>
    <year>2007</year>
    <article-title>Singh, Nanotechnology-based drug delivery systems, J.Occup</article-title>
    <source>Med. Toxicol</source>
    Suri, S. S. H., &amp;Fenniri, B. (2007) Singh, Nanotechnology-based drug delivery systems, J.Occup. Med. Toxicol. 1, 2â€“16.
  </mixed-citation>
</ref>
<ref id="Roco">
  <label>2</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Roco, M. C</person-group>
    <year>2003</year>
    <article-title>. Nanotechnology: convergence with modern biology and medicine, Curr</article-title>
    <source>Opin. Biotechnol</source>
    Roco, M. C. (2003). Nanotechnology: convergence with modern biology and medicine, Curr. Opin. Biotechnol. 14, 337â€“346.
  </mixed-citation>
</ref>
<ref id="Torchilin">
  <label>3</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Torchilin, V. P</person-group>
    <year>2008</year>
    <article-title>. Nanotechnology in Drugs, second ed</article-title>
    <source>Imperial College Press,London</source>
    <page-range>ress</page-range>
    Torchilin, V. P. (2008). Nanotechnology in Drugs, second ed. Imperial College Press,London,
  </mixed-citation>
</ref>
<ref id="Sahoo">
  <label>4</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Sahoo, S. K. V</person-group>
    <year>2008</year>
    <article-title>. Labhasetwar, Nanotech approaches to drug delivery and imaging, Drug Discov</article-title>
    <source>Today</source>
    Sahoo, S. K. V. (2008). Labhasetwar, Nanotech approaches to drug delivery and imaging, Drug Discov. Today 8, 1112â€“1120.
  </mixed-citation>
</ref>
<ref id="Couvreur">
  <label>5</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Couvreur, P. C</person-group>
    <year>2006</year>
    <article-title>. Vauthier, Nanotechnology: intelligent design to treat complex disease, Pharm</article-title>
    <source>Res</source>
    <page-range>C</page-range>
    Couvreur, P. C. (2006). Vauthier, Nanotechnology: intelligent design to treat complex disease, Pharm. Res. 23, 1417â€“1450.
  </mixed-citation>
</ref>
<ref id="Kumar">
  <label>6</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Kumar, R. M. N</person-group>
    <year>2000</year>
    <article-title>. Nano and microparticles as controlled drug delivery devices, J.Pharm</article-title>
    <source>Pharm. Sci</source>
    <page-range>harm</page-range>
    Kumar, R. M. N. (2000). Nano and microparticles as controlled drug delivery devices, J.Pharm. Pharm. Sci. 3, 234â€“258.
  </mixed-citation>
</ref>
<ref id="Liu">
  <label>7</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Liu, Z, Y. Jiao, Y. Wang, C. Zhou, Z. Zhang</person-group>
    <year>2008</year>
    <article-title>. Polysaccharides-based nanoparticles as drug delivery systems, Adv</article-title>
    <source>Drug Deliv. Rev</source>
    <page-range>olysaccharides-based</page-range>
    Liu, Z, Y. Jiao, Y. Wang, C. Zhou, Z. Zhang. (2008). Polysaccharides-based nanoparticles as drug delivery systems, Adv. Drug Deliv. Rev. 60, 1650â€“1662.
  </mixed-citation>
</ref>
<ref id="FernandezUrrusuno">
  <label>8</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Fernandez-Urrusuno, P., Calvo, C., Remunan- Lopez, J., L. &amp; Vila-Jato, M. J</person-group>
    <year>1999</year>
    <article-title>. Alonso, Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm</article-title>
    <source>Res</source>
    <page-range>harm</page-range>
    Fernandez-Urrusuno, P., Calvo, C., Remunan- Lopez, J., L. &amp; Vila-Jato, M. J. (1999). Alonso, Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm. Res. 16, 1576â€“1581.
  </mixed-citation>
</ref>
<ref id="Farrugia">
  <label>9</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Farrugia, M. J</person-group>
    <year>1999</year>
    <article-title>. Groves, the activity of unloaded gelatin nanoparticles on murine B16-F0 melanoma growth in vivo, Anticancer</article-title>
    <source>Res</source>
    Farrugia, M. J. (1999). Groves, the activity of unloaded gelatin nanoparticles on murine B16-F0 melanoma growth in vivo, Anticancer. Res. 19, 1027â€“1031.
  </mixed-citation>
</ref>
<ref id="Fattal">
  <label>10</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Fattal, C. Vauthier, I. Aynie, Y. Nakada, G. Lambert, C. Malvy, P</person-group>
    <year>1998</year>
    <article-title>. Couvreur, Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides, J</article-title>
    <source>Control. Release</source>
    <page-range>olyalkylcyanoacrylate</page-range>
    Fattal, C. Vauthier, I. Aynie, Y. Nakada, G. Lambert, C. Malvy, P. (1998). Couvreur, Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides, J. Control. Release 53, 137â€“ 143.
  </mixed-citation>
</ref>
<ref id="Breunig">
  <label>11</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Breunig, S. Bauer, A</person-group>
    <year>2008</year>
    <article-title>. Goepferich, Polymers and nanoparticles: intelligent tools for intracellular targeting? Eur</article-title>
    <source>J. Pharm. Biopharm</source>
    <page-range>olymers</page-range>
    Breunig, S. Bauer, A. (2008). Goepferich, Polymers and nanoparticles: intelligent tools for intracellular targeting? Eur. J. Pharm. Biopharm. 68, 112â€“128
  </mixed-citation>
</ref>
<ref id="Kuijpers">
  <label>12</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Kuijpers, P.B. van Wachem, M.J.A. van Luyn, L.A. Brouwer, G.H.M. Engbers, J. Krijgsveld</person-group>
    <year>2000</year>
    <source>In vitro and in vivo evaluation of gelatin chondroitin sulphate hydrogels for controlled release of antibacterial proteins, Biomaterials</source>
    <page-range>B</page-range>
    Kuijpers, P.B. van Wachem, M.J.A. van Luyn, L.A. Brouwer, G.H.M. Engbers, J. Krijgsveld, (2000). In vitro and in vivo evaluation of gelatin chondroitin sulphate hydrogels for controlled release of antibacterial proteins, Biomaterials 21, 1763â€“1772.
  </mixed-citation>
</ref>
<ref id="Elzoghby">
  <label>13</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Elzoghby, W.S. Abo El-Fotoh, N. A</person-group>
    <year>2011</year>
    <article-title>. Elgindy, Casein-based formulations as promising controlled release drug delivery systems, J</article-title>
    <source>Control. Release</source>
    <page-range>romising</page-range>
    Elzoghby, W.S. Abo El-Fotoh, N. A. (2011). Elgindy, Casein-based formulations as promising controlled release drug delivery systems, J. Control. Release 153, 206â€“216.
  </mixed-citation>
</ref>
<ref id="Vandelli">
  <label>14</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Vandelli, F. Rivasi, P. Guerra, F. Forni, R</person-group>
    <year>2001</year>
    <article-title>. Arletti, Gelatin microspheres crosslinked with d, l-glyceraldehyde as a potential drug delivery system: preparation, characterization, in vitro and in vivo studies, Int</article-title>
    <source>J. Pharm</source>
    <page-range>Guerra</page-range>
    Vandelli, F. Rivasi, P. Guerra, F. Forni, R. (2001). Arletti, Gelatin microspheres crosslinked with d, l-glyceraldehyde as a potential drug delivery system: preparation, characterization, in vitro and in vivo studies, Int. J. Pharm. 215, 175â€“184.
  </mixed-citation>
</ref>
<ref id="Sahin">
  <label>15</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Sahin, H. Selek, G. Ponchel, M.T. Ercan, M.A. Sargon, A. Hincal, H.S</person-group>
    <year>2002</year>
    <article-title>. Kas, Preparation, characterization and in vivo distribution of terbutaline sulfate loaded albumin microspheres, J</article-title>
    <source>Control. Release</source>
    <page-range>onchel</page-range>
    Sahin, H. Selek, G. Ponchel, M.T. Ercan, M.A. Sargon, A. Hincal, H.S. (2002). Kas, Preparation, characterization and in vivo distribution of terbutaline sulfate loaded albumin microspheres, J. Control. Release 82, 345â€“358.
  </mixed-citation>
</ref>
<ref id="Langer">
  <label>16</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Langer, S. Balthasar, V. Vogel, N. Dinauer, H. von Briesen, D</person-group>
    <year>2003</year>
    <article-title>. Schubert Optimization of the preparation process for human serum albumin (HSA) nanoparticles, Int</article-title>
    <source>J. Pharm</source>
    <page-range>reparation</page-range>
    Langer, S. Balthasar, V. Vogel, N. Dinauer, H. von Briesen, D. (2003). Schubert Optimization of the preparation process for human serum albumin (HSA) nanoparticles, Int. J. Pharm. 257, 169â€“180.
  </mixed-citation>
</ref>
<ref id="Rubino">
  <label>17</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Rubino, R. Kowalsky, J</person-group>
    <year>1993</year>
    <article-title>. Swarbrick, Albumin microspheres as a drug delivery system: relation among turbidity ratio, degree of cross-linking and drug release, Pharm</article-title>
    <source>Res</source>
    <page-range>harm</page-range>
    Rubino, R. Kowalsky, J. (1993). Swarbrick, Albumin microspheres as a drug delivery system: relation among turbidity ratio, degree of cross-linking and drug release, Pharm. Res. 10, 1059â€“1065.
  </mixed-citation>
</ref>
<ref id="Kommareddy">
  <label>18</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Kommareddy, M</person-group>
    <year>2005</year>
    <article-title>. Amiji, Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione, Bioconjug</article-title>
    <source>Chem</source>
    <page-range>reparation</page-range>
    Kommareddy, M. (2005). Amiji, Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione, Bioconjug. Chem. 16, 1423â€“1432.
  </mixed-citation>
</ref>
<ref id="Azarmi">
  <label>19</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Azarmi, X. Tao, H. Chen, Z. Wang, W.H. Finlay, R</person-group>
    <year>2006</year>
    <article-title>. LÃ¶benberg, W.H</article-title>
    <source>Roa, Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles, Int. J. Pharm</source>
    <page-range>owder</page-range>
    Azarmi, X. Tao, H. Chen, Z. Wang, W.H. Finlay, R. (2006). LÃ¶benberg, W.H. Roa, Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles, Int. J. Pharm. 319, 155â€“161.
  </mixed-citation>
</ref>
<ref id="Kratz">
  <label>20</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Kratz, I. Fichtner, P. Schumarcher, T</person-group>
    <year>1997</year>
    <article-title>. Roth, H.H</article-title>
    <source>Feibig, C. Unger, Antitumoractivity of acid labile transferrin and albumin doxorubicin conjugates in vitro and in vivo human tumor xerograft models, Eur. J. Cancer</source>
    <page-range>Schumarcher</page-range>
    Kratz, I. Fichtner, P. Schumarcher, T. (1997). Roth, H.H. Feibig, C. Unger, Antitumoractivity of acid labile transferrin and albumin doxorubicin conjugates in vitro and in vivo human tumor xerograft models, Eur. J. Cancer 33, S175.
  </mixed-citation>
</ref>
<ref id="Rahimnejad">
  <label>21</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Rahimnejad, M. Jahanshahi, G.D</person-group>
    <year>2006</year>
    <article-title>. Najafpour, Production of biological nanoparticles from bovine serum albumin for drug delivery, Afr</article-title>
    <source>J. Biotechnol.5, 1918â€“1923</source>
    <page-range>roduction</page-range>
    Rahimnejad, M. Jahanshahi, G.D. (2006). Najafpour, Production of biological nanoparticles from bovine serum albumin for drug delivery, Afr. J. Biotechnol.5, 1918â€“1923
  </mixed-citation>
</ref>
<ref id="Fasano">
  <label>22</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Fasano, M., Curry, S., &amp; Terreno, E</person-group>
    <year>2005</year>
    <article-title>. The extraordinary ligand binding properties human serum albumin</article-title>
    <source>IUBMB Life</source>
    <page-range>roperties</page-range>
    Fasano, M., Curry, S., &amp; Terreno, E. (2005). The extraordinary ligand binding properties human serum albumin. IUBMB Life 57, 787â€“ 79
  </mixed-citation>
</ref>
<ref id="Droge">
  <label>23</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Droge, W., Schulze-Osthoff, K., &amp; Mihm, S</person-group>
    <year>1994</year>
    <article-title>. Functions of glutathione and glutathione disulfide in immunology and immunopathology</article-title>
    <source>FASEB J</source>
    Droge, W., Schulze-Osthoff, K., &amp; Mihm, S, (1994). Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J, 8, 1131â€“1138
  </mixed-citation>
</ref>
<ref id="Stohl">
  <label>24</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Stohl, W</person-group>
    <year>1996</year>
    <article-title>. Elliot JE: In vitro inhibition by intravenous immunoglobulin of human cell- dependent B cell differentiation induced by staphylococcal superantigens</article-title>
    <source>Clin Immunol Immunopathol</source>
    Stohl, W. (1996). Elliot JE: In vitro inhibition by intravenous immunoglobulin of human cell- dependent B cell differentiation induced by staphylococcal superantigens. Clin Immunol Immunopathol, 79, 122â€“133
  </mixed-citation>
</ref>
<ref id="Crow">
  <label>25</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Crow, A. R., Song, S., &amp; Semple, J. W</person-group>
    <year>2001</year>
    <article-title>. IVIg inhibits reticuloendothelial system function and ameliorates murine passive- immune thrombocytopenia independent of antidiotype reactivity</article-title>
    <source>Br J Haematol</source>
    <page-range>assive-</page-range>
    Crow, A. R., Song, S., &amp; Semple, J. W. (2001). IVIg inhibits reticuloendothelial system function and ameliorates murine passive- immune thrombocytopenia independent of antidiotype reactivity. Br J Haematol, 115, 679â€“686
  </mixed-citation>
</ref>
<ref id="Ephrem">
  <label>26</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Ephrem, A., Chamat, S., &amp; Miquel, C</person-group>
    <year>2008</year>
    <article-title>. Expansion of CD4+ CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis</article-title>
    <source>Blood</source>
    Ephrem, A., Chamat, S., &amp; Miquel, C, (2008). Expansion of CD4+ CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood, 111, 715â€“722
  </mixed-citation>
</ref>
<ref id="KraghHansen">
  <label>27</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Kragh-Hansen, U</person-group>
    <year>2013</year>
    <article-title>. Molecular and practical aspects of the enzymatic properties of human serum albumin and of albumin-ligand complexes</article-title>
    <source>Biochim Biophys Acta</source>
    <volume>1830</volume>
    <issue>12</issue>
    <fpage>5535</fpage>
    <lpage>44</lpage>
    Kragh-Hansen, U. (2013). Molecular and practical aspects of the enzymatic properties of human serum albumin and of albumin-ligand complexes. Biochim Biophys Acta , 1830(12), 5535-44
  </mixed-citation>
</ref>
<ref id="Liumbruno">
  <label>29</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Liumbruno, G. M., Bennardello, F., Lattanzio, A., Piccoli, P., &amp; Rossettias, G</person-group>
    <year>2009</year>
    <article-title>. Recommendations for the use of albumin and immunoglobulins</article-title>
    <source>Blood Transfus</source>
    <volume>7</volume>
    <issue>3</issue>
    <fpage>216</fpage>
    Liumbruno, G. M., Bennardello, F., Lattanzio, A., Piccoli, P., &amp; Rossettias, G. (2009). Recommendations for the use of albumin and immunoglobulins. Blood Transfus, 7(3):216- 34
  </mixed-citation>
</ref>
<ref id="Dugaiczyk">
  <label>30</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Dugaiczyk, A., Law, S. W., &amp; Dennison, O. E</person-group>
    <year>1982</year>
    <article-title>. Nucleotide sequence and the encoded amino acids of human serum albumin mrna</article-title>
    <source>Proc Natl Acad Sci USA</source>
    <volume>79</volume>
    <issue>1</issue>
    <fpage>71</fpage>
    <lpage>5</lpage>
    Dugaiczyk, A., Law, S. W., &amp; Dennison, O. E. (1982). Nucleotide sequence and the encoded amino acids of human serum albumin mrna. Proc Natl Acad Sci USA , 79(1):71-5
  </mixed-citation>
</ref>
<ref id="Gerety">
  <label>31</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Gerety, R. J., &amp; Aronson, D. L</person-group>
    <year>1982</year>
    <article-title>. Plasma derivatives and viral hepatitis</article-title>
    <source>Transfusion</source>
    <volume>22</volume>
    <issue>5</issue>
    <fpage>347</fpage>
    <lpage>51</lpage>
    Gerety, R. J., &amp; Aronson, D. L. (1982). Plasma derivatives and viral hepatitis. Transfusion, 22(5):347-51.
  </mixed-citation>
</ref>
<ref id="Clowes">
  <label>32</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Clowes, G. H. J., Vucinic, M., &amp; Weidner, M. G</person-group>
    <year>1966</year>
    <article-title>. Circulatory and metabolic alterations associated with survival or death in peritonitis: Clinical analysis of 25 cases</article-title>
    <source>Ann Surg</source>
    <volume>163</volume>
    <issue>6</issue>
    <fpage>866</fpage>
    <lpage>85</lpage>
    Clowes, G. H. J., Vucinic, M., &amp; Weidner, M. G. (1966). Circulatory and metabolic alterations associated with survival or death in peritonitis: Clinical analysis of 25 cases. Ann Surg, 163(6):866-85
  </mixed-citation>
</ref>
<ref id="Chen">
  <label>33</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Chen, Z., He, Y., Shi, B., &amp; Yang, D</person-group>
    <year>2013</year>
    <article-title>. Human serum albumin from recombinant DNA technology:Challenges and strategies</article-title>
    <source>Biochim Biophys Acta</source>
    <volume>1830</volume>
    <issue>12</issue>
    <fpage>5515</fpage>
    <lpage>25</lpage>
    Chen, Z., He, Y., Shi, B., &amp; Yang, D. (2013). Human serum albumin from recombinant DNA technology:Challenges and strategies. Biochim Biophys Acta, 1830(12):5515-25
  </mixed-citation>
</ref>
<ref id="Raoufinia">
  <label>34</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Raoufinia, R., Mota, A., Nozari, S., Aghebati, M. L., Balkani, S., &amp; Abdolalizadeh, J</person-group>
    <year>2016</year>
    <article-title>. A methodological approach for purification and characterization of human serum albumin</article-title>
    <source>J Immunoassay Immunochem</source>
    <volume>37</volume>
    <issue>6</issue>
    <fpage>623</fpage>
    <lpage>35</lpage>
    Raoufinia, R., Mota, A., Nozari, S., Aghebati, M. L., Balkani, S., &amp; Abdolalizadeh, J. (2016). A methodological approach for purification and characterization of human serum albumin. J Immunoassay Immunochem, 37(6):623-35
  </mixed-citation>
</ref>
<ref id="He">
  <label>35</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">He, Y., Ning, T., Xie, T., Qiu, Q., Zhang, L., &amp; Sun, Y</person-group>
    <year>2011</year>
    <article-title>. Large-scale production offunctional human serum albumin from transgenic rice seeds</article-title>
    <source>Proc Nat Acad Sci USA</source>
    <volume>108</volume>
    <issue>47</issue>
    <fpage>19078</fpage>
    He, Y., Ning, T., Xie, T., Qiu, Q., Zhang, L., &amp; Sun, Y. (2011). Large-scale production offunctional human serum albumin from transgenic rice seeds. Proc Nat Acad Sci USA, 108(47):19078- 83
  </mixed-citation>
</ref>
<ref id="Hage">
  <label>37</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Hage, D. S., Anguizola, J. A., Bi, C., Li, R., Matsuda, R., &amp; Papastavros, E</person-group>
    <year>2012</year>
    <article-title>. Pharmaceutical and biomedical applications of affinitychromatography: Recent trends and developments</article-title>
    <source>J Pharm Biomed Anal</source>
    <page-range>apastavros</page-range>
    Hage, D. S., Anguizola, J. A., Bi, C., Li, R., Matsuda, R., &amp; Papastavros, E, (2012). Pharmaceutical and biomedical applications of affinitychromatography: Recent trends and developments. J Pharm Biomed Anal, 69, 93- 105
  </mixed-citation>
</ref>
<ref id="Abdolalizadeh">
  <label>38</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Abdolalizadeh, J., Nouri, M., Zolbanin, J. M., Barzegari, A., Baradaran, B., &amp; Barar, J</person-group>
    <year>2013</year>
    <article-title>. Targeting cytokines: Production and characterization of antiTNF-alpha scFvs by phage display technology</article-title>
    <source>Curr Pharm Des</source>
    <volume>19</volume>
    <issue>15</issue>
    <fpage>2839</fpage>
    <lpage>47</lpage>
    Abdolalizadeh, J., Nouri, M., Zolbanin, J. M., Barzegari, A., Baradaran, B., &amp; Barar, J. (2013). Targeting cytokines: Production and characterization of antiTNF-alpha scFvs by phage display technology. Curr Pharm Des, 19(15), 2839-47.
  </mixed-citation>
</ref>
<ref id="Cuatrecasas">
  <label>41</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Cuatrecasas, P., Wilchek, M., &amp; Anfinsen, C. B</person-group>
    <year>1968</year>
    <article-title>. Selective enzyme purification byaffinity chromatography</article-title>
    <source>Proc Natl Acad Sci USA</source>
    <volume>61</volume>
    <issue>2</issue>
    <fpage>636</fpage>
    <lpage>43</lpage>
    Cuatrecasas, P., Wilchek, M., &amp; Anfinsen, C. B. (1968). Selective enzyme purification byaffinity chromatography. Proc Natl Acad Sci USA, 61(2), 636-43
  </mixed-citation>
</ref>
<ref id="Moore">
  <label>42</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Moore, S., &amp; Stein, W. H</person-group>
    <year>1956</year>
    <article-title>. Column chromatography of peptides and proteins</article-title>
    <source>Adv. Protein Chem</source>
    <volume>11</volume>
    <fpage>191</fpage>
    <lpage>236</lpage>
    Moore, S., &amp; Stein, W. H. (1956). Column chromatography of peptides and proteins. Adv. Protein Chem., 11, 191-236.
  </mixed-citation>
</ref>
<ref id="William">
  <label>43</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">William, W</person-group>
    <year>2009</year>
    <source>Ward and Gavin Swiatek, Protein Purification, Current Analytical Chemistry</source>
    <volume>5</volume>
    <fpage>000</fpage>
    William, W. (2009). Ward and Gavin Swiatek, Protein Purification, Current Analytical Chemistry, 5,000-000
  </mixed-citation>
</ref>
<ref id="Kovacs">
  <label>44</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Kovacs, A., &amp; Guttman, A</person-group>
    <year>2013</year>
    <article-title>. Medicinal chemistry meets proteomics: Fractionation of the human plasma proteome</article-title>
    <source>Curr Med Chem</source>
    <volume>20</volume>
    <issue>4</issue>
    <fpage>483</fpage>
    <lpage>90</lpage>
    Kovacs, A., &amp; Guttman, A. (2013). Medicinal chemistry meets proteomics: Fractionation of the human plasma proteome. Curr Med Chem, 20(4), 483-90
  </mixed-citation>
</ref>
<ref id="Vasileva">
  <label>45</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Vasileva, R., Jakab, M., &amp; Hasko, F</person-group>
    <year>1981</year>
    <article-title>. Application of ionexchange chromatography for the production of human albumin</article-title>
    <source>J Chromatogr</source>
    <volume>216</volume>
    <fpage>279</fpage>
    <lpage>84</lpage>
    Vasileva, R., Jakab, M., &amp; Hasko, F. (1981). Application of ionexchange chromatography for the production of human albumin. J Chromatogr, 216, 279-84
  </mixed-citation>
</ref>
<ref id="Aghebati">
  <label>47</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Aghebati, M. A</person-group>
    <year>2013</year>
    <article-title>. Large scale generation and characterization of anti-human cd34 monoclonal antibody in ascetic fluid of balb/c mice</article-title>
    <source>Adv Pharm Bull</source>
    <volume>3</volume>
    <issue>1</issue>
    <fpage>211</fpage>
    <lpage>6</lpage>
    Aghebati, M. A. (2013). Large scale generation and characterization of anti-human cd34 monoclonal antibody in ascetic fluid of balb/c mice. Adv Pharm Bull, 3(1), 211-6
  </mixed-citation>
</ref>
<ref id="Frerick">
  <label>48</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Frerick, C., Kreis, P., Gorak, A., &amp; Melzner, D</person-group>
    <year>2006</year>
    <article-title>. Simulation and optimisation of the downstream process for purification of human serum albumin by using ion exchange membrane adsorbers</article-title>
    <source>Desalination</source>
    <page-range>rocess</page-range>
    Frerick, C., Kreis, P., Gorak, A., &amp; Melzner, D. (2006). Simulation and optimisation of the downstream process for purification of human serum albumin by using ion exchange membrane adsorbers. Desalination, 200 (1-3), 468-9
  </mixed-citation>
</ref>
<ref id="Ramin">
  <label>50</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Ramin, R., Ali, M., Neda, K., Fatemeh, S., Sara, S., &amp; Jalal, A</person-group>
    <year>2016</year>
    <article-title>. Overview of protein ad its purification</article-title>
    <source>Adv pharm bull</source>
    <volume>6</volume>
    <issue>4</issue>
    <fpage>495</fpage>
    <lpage>507</lpage>
    Ramin, R., Ali, M., Neda, K., Fatemeh, S., Sara, S., &amp; Jalal, A. (2016). Overview of protein ad its purification. Adv pharm bull, 6(4), 495-507.
  </mixed-citation>
</ref>
<ref id="Denizli">
  <label>51</label>
  <mixed-citation publication-type="journal">
    <person-group person-group-type="author">Denizli, A</person-group>
    <year>2011</year>
    <article-title>. Plasma fractionation: Conventional and chromatographic methods for albumin purification</article-title>
    <source>Hacettepe J Biol Chem</source>
    <volume>39</volume>
    <issue>4</issue>
    <fpage>315</fpage>
    <lpage>41</lpage>
    Denizli, A. (2011). Plasma fractionation: Conventional and chromatographic methods for albumin purification. Hacettepe J Biol Chem 39(4), 315-41.
  </mixed-citation>
</ref>
</ref-list>
</back>
</article>