http://dx.doi.org/10.31703/gdddr.2022(VII-I).03
10.31703/gdddr.2022(VII-I).03
Published : Mar 2022
Management of Psychiatric and Neurological Comorbidities in Epilepsy
People with epilepsy often have between 30 and 50% of their patients with neuropsychiatric disorders. The major neurological comorbidities linked with epilepsy, such as migraine, dementia, traumatic brain injury, and autism spectrum disorder, have relative effects on some of the psychiatric disorders, such as mood and anxiety disorders. The current research objective was to report the usage of pharmacologic drugs in the treatment of a neuropsychiatric disorder in epilepsy. A total of 630 patients of different aged groups (9-18 years, between 19-64 years and Elderly > 65 years) were included in our research. The study was carried out at Qazi Hussain Ahmed Medical Complex Nowshera from September 2021 to Jan 2022. Epilepsy patients in rural areas had a substantially lower incidence of neuropsychiatric disorders than those in urban areas, and most of the patients were men. The most often used Anti epilepsy drugs (AEDs) for treating epilepsy were lamotrigine, valproate, and levetiracetam, which were used by 50% of participants. Carbamazepine was only used by adults and was least frequently utilized by older people. In order to effectively manage neuro-psychiatric comorbidities in epilepsy, it is important to consider both possible iatrogenic and therapeutic consequences.
-
Psychiatric & Neurological Comorbidities, Epilepsy, Neuropsychiatric Disorders
-
(1) Ali Ahsan Mufti
Associate Professor, Department of Psychiatry, Jinnah Medical College Peshawar, Ibadat Hospital Peshawar, KP, Pakistan.
(2) Muhammad Kamran Khan
Assistant Professor, Department of Psychiatry, Qazi Hussain Ahmed Medical Complex Nowshera, KP, Pakistan.
(3) Ghaazaan Khan
Assistant Professor, Department of Psychiatry, Jinnah Medical College Peshawar, KP, Pakistan.
(4) Khalil Azam
Assistant Professor, Department of Psychiatry, Qazi Hussain Ahmed Medical Complex Nowshera, KP, Pakistan.
- Banerjee, P. N., Filippi, D., & Allen Hauser, W. (2009). The descriptive epidemiology of epilepsy—A review. Epilepsy Research, 85(1), 31– 45. https://doi.org/10.1016/j.eplepsyres.2009.03.003
- Breslau, N., Lipton, R. B., Stewart, W. F., Schultz, L. R., & Welch, K. M. (2003). Comorbidity of migraine and depression: Investigating potential etiology and prognosis. Neurology, 60(8), 1308– 1312. https://doi.org/10.1212/01.wnl.0000058907.41080.54
- Chiang, K. L., & Cheng, C. Y. (2014). Prevalence and neuro-psychiatric comorbidities of pediatric epilepsy in Taiwan: A national population-based study. Epilepsy Research, 108(8), 1451– 1460. https://doi.org/10.1016/j.eplepsyres.2014.07.004
- Chien, I. C., Lin, C. H., Chou, Y. J., & Chou, P. (2012). Prevalence, incidence, and stimulant use of attention-deficit hyperactivity disorder in Taiwan, 1996–2005: a national population-based study. Social Psychiatry and Psychiatric Epidemiology, 47(12), 1885– 1890. https://doi.org/10.1007/s00127-012-0501-1
- Devinsky, O. (2003). Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment. Epilepsy &Amp; Behavior, 4, 2– 10. https://doi.org/10.1016/j.yebeh.2003.10.002
- Gaitatzis, A., Trimble, M. R., & Sander, J. W. (2004). The psychiatric comorbidity of epilepsy. Acta Neurologica Scandinavica, 110(4), 207– 220. https://doi.org/10.1111/j.1600-0404.2004.00324.x
- Hesdorffer, D. C., LúðvÃgsson, P., Hauser, W. A., Ólafsson, E., & Kjartansson, L. (2007). Co- occurrence of major depression or suicide attempt with migraine with aura and risk for unprovoked seizure. Epilepsy Research, 75(2–3), 220– 223. https://doi.org/10.1016/j.eplepsyres.2007.05.001
- Kanner, A. M. (2003). Depression in epilepsy: a frequently neglected multifaceted disorder. Epilepsy &Amp; Behavior, 4, 11– 19. https://doi.org/10.1016/j.yebeh.2003.10.004
- Kanner, A. M. (2016). Management of psychiatric and neurological comorbidities in epilepsy. Nature Reviews Neurology, 12(2), 106– 116. https://doi.org/10.1038/nrneurol.2015.243
- Kanner, A. M. (2016). Management of psychiatric and neurological comorbidities in epilepsy. Nature Reviews Neurology, 12(2), 106– 116. https://doi.org/10.1038/nrneurol.2015.243
- Kanner, A. M. (2017). Psychiatric comorbidities in new onset epilepsy: Should they be always investigated? Seizure, 49, 79– 82. https://doi.org/10.1016/j.seizure.2017.04.007
- Kanner, A. M., & Balabanov, A. (2002). Depression and epilepsy: How closely related are they? Neurology, 58(Issue 8, Supplement 5), S27 S39. https://doi.org/10.1212/wnl.58.8_suppl_5.s27
- Karouni, M., Arulthas, S., Larsson, P. G., Rytter, E., Johannessen, S. I., & Johannessen Landmark, C. (2010). Psychiatric comorbidity in patients with epilepsy: a population-based study. European Journal of Clinical Pharmacology, 66(11), 1151– 1160. https://doi.org/10.1007/s00228-010-0861-y
- Larson, S. L., Owens, P. L., Ford, D., & Eaton, W. (2001). Depressive disorder, dysthymia, and risk of stroke: thirteen-year follow-up from the Baltimore Epidemiological Catchment Area Study. Stroke 32, 1979– 1983.
- Laxer, K. D., Trinka, E., Hirsch, L. J., Cendes, F., Langfitt, J., Delanty, N., Resnick, T., & Benbadis, S. R. (2014). The consequences of refractory epilepsy and its treatment. Epilepsy &Amp; Behavior, 37, 59– 70. https://doi.org/10.1016/j.yebeh.2014.05.031
- Lopez, M. R., Schachter, S. C., & Kanner, A. M. (2019). Psychiatric comorbidities go unrecognized in patients with epilepsy: “You see what you know.†Epilepsy &Amp; Behavior, 98, 302– 305. https://doi.org/10.1016/j.yebeh.2019.01.027
- McHugh, J. C., & Delanty, N. (2008). Epidemiology and classification of epilepsy: gender comparisons. International review of neurobiology, 83, 11-26.
- Stoyan Popkirov, Ali A. Asadi-Pooya, Roderick Duncan, David Gigineishvili, Coraline Hingray, Andres M. Kanner, W. Curt LaFrance, Chrisma Pretorius, & Markus Reuber. (2019). The aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities. Epileptic Disorders, 21(6), 529– 547. https://doi.org/10.1684/epd.2019.1107
- Stephen, L. J., Forsyth, M., Kelly, K., & Brodie, M. J. (2012). Antiepileptic drug combinations—Have newer agents altered clinical outcomes? Epilepsy Research, 98(2– 3), 194– 198. https://doi.org/10.1016/j.eplepsyres.2011.09.008
- Tellez-Zenteno, J. F., Patten, S. B., Jetté, N., Williams, J., & Wiebe, S. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 48, 2336–2344 (2007). https://doi.org/10.1111/j.1528-1167.2007.01222.x
Cite this article
-
APA : Mufti, A. A., Khan, M. K., & Khan, G. (2022). Management of Psychiatric and Neurological Comorbidities in Epilepsy. Global Drug Design & Development Review, VII(I), 18-25. https://doi.org/10.31703/gdddr.2022(VII-I).03
-
CHICAGO : Mufti, Ali Ahsan, Muhammad Kamran Khan, and Ghaazaan Khan. 2022. "Management of Psychiatric and Neurological Comorbidities in Epilepsy." Global Drug Design & Development Review, VII (I): 18-25 doi: 10.31703/gdddr.2022(VII-I).03
-
HARVARD : MUFTI, A. A., KHAN, M. K. & KHAN, G. 2022. Management of Psychiatric and Neurological Comorbidities in Epilepsy. Global Drug Design & Development Review, VII, 18-25.
-
MHRA : Mufti, Ali Ahsan, Muhammad Kamran Khan, and Ghaazaan Khan. 2022. "Management of Psychiatric and Neurological Comorbidities in Epilepsy." Global Drug Design & Development Review, VII: 18-25
-
MLA : Mufti, Ali Ahsan, Muhammad Kamran Khan, and Ghaazaan Khan. "Management of Psychiatric and Neurological Comorbidities in Epilepsy." Global Drug Design & Development Review, VII.I (2022): 18-25 Print.
-
OXFORD : Mufti, Ali Ahsan, Khan, Muhammad Kamran, and Khan, Ghaazaan (2022), "Management of Psychiatric and Neurological Comorbidities in Epilepsy", Global Drug Design & Development Review, VII (I), 18-25
-
TURABIAN : Mufti, Ali Ahsan, Muhammad Kamran Khan, and Ghaazaan Khan. "Management of Psychiatric and Neurological Comorbidities in Epilepsy." Global Drug Design & Development Review VII, no. I (2022): 18-25. https://doi.org/10.31703/gdddr.2022(VII-I).03